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Caroline Willoughby, later Clark, (1863-1945) was one of the original five members of staff at Westfield College. She was Resident Lecturer in Science from 1885 until 1894.

She was educated at Plymouth High School for girls, where her Westfield colleague Frances Ralph Gray also studied. Plymouth High School was one of forty new schools for girls established by the Endowed Schools Commissioners and the Girls' Public Day Schools Company by 1882.

Willoughby went on to read for the Natural Sciences tripos at Newnham College, Cambridge. She became Science Lecturer at Westfield in 1885, and, according to Sondheimer, she was regarded as an authority on all practical matters due to her scientific training.

In 1895, she married Dr William Adams Clark, MD. She passed the London Society of Apothecaries Assistant's Examination in 1896, and then she worked alongside her husband at his medical practice in Penge.